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What drugs can cause a false positive on a drug screen? These 15 Medications Can Cause a False Positive on Drug Tests 1) Amitriptyline (Amitril) 2) Bupropion (Wellbutrin) 3) Dextromethorphan (Robitussin, Delsym) 4) Diltiazem (Cardizem) 5) Diphenhydramine (Benadryl) 6) Ibuprofen (Motrin, Advil) and naproxen (Aleve) 7) Metformin (Glucophage) 8) Fluoxetine (Prozac) and trazodone.
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